L-theanine as Suntheanine® (standardized to >99%): Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA, and decreasing norepinephrine levels in the brain.*1,2
5-HTP: A naturally occurring amino acid and metabolite of L– tryptophan. 5-HTP is the direct precursor in the biosynthesis of serotonin.* Use of 5-HTP avoids the rate-limiting conversion of tryptophan to 5-HTP.
Glycine: Functions as an inhibitory neurotransmitter, primarily in the brainstem and spinal cord.*3
Vitamin B6 (as pyridoxal-5’-phosphate): Active form of B6. Cofactor in conversion of 5-HTP to serotonin.*
NeuroSupport Blend™ (NSB): Proprietary mixture composed of Bioperine® and plant-based enzymes clinically proven to maximize nutrient absorption.*
References:
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- Longone P, et al. Frontiers in endocrinology. (2011):2.
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- Wurtman J and Wurtman R. Curr Obes. Rep. 2018 Mar;7(1):1-5.
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- Hull EM, et al. Physiology and Behavior. 2004 Nov;83(2):291-307.
- Crowell MD. Br J Pharmacol. 2004 Apr;141(8):1285-93.
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- Bravo R, et. al. Age (Dordr). 2013 Aug;35(4):1277-86.
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- Lynch JW. Physiol Rev. 2004 Oct ;84(4):1051-95.
- Miraucourt LS, et al. J Neurosci. 2009 Feb 25;29(8):2519-27.
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- McCarty MF, O’Keefe JH, DiNicolantonio JJ. Ochsner J. 2018 ;18(1):81-87.
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- Frenkel L, Muraro NI, Beltrán González AN, et al. (2017 Apr 4). Organization of Circadian Behavior Relies on Glycinergic Transmission. Cell Rep. 19(1):72-85.
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