Prolent™ by Sanesco — Inhibitory Neurotransmission Support

L-theanine as Suntheanine® (standardized to >99%): Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA, and decreasing norepinephrine levels in the brain.*^1,2

5-HTP: A naturally occurring amino acid and metabolite of L– tryptophan. 5-HTP is the direct precursor in the biosynthesis of serotonin.* Use of 5-HTP avoids the rate-limiting conversion of tryptophan to 5-HTP. 

Glycine: Functions as an inhibitory neurotransmitter, primarily in the brainstem and spinal cord.*³

Vitamin B6 (as pyridoxal-5’-phosphate): Active form of B6. Cofactor in conversion of 5-HTP to serotonin.* 

NeuroSupport Blend™ (NSB): Proprietary mixture composed of Bioperine® and plant-based enzymes clinically proven to maximize nutrient absorption.* 

References:

1. Eschenauer G and Sweet BV. Am J Healthy-Syst Pharm. 2006 Jan 1;63(1):26-30.  
2. Kakuda T, et al. Biosci Biotechnol Biochem. 2002;66(12):2683–2686.
3. Bannai M, et al. Psychiatry and Clinical Neurosciences. 2011 Mar;65(2), 142-149.
4. Ngo D and Vo TS. Molecules. 2019;24(15):2678. 
5. Longone P, et al. Frontiers in endocrinology. (2011):2.  
6. Moller SE. (1992). Serotonin, carbohydrates, and atypical depression. Pharmacol Toxicol. 71 Suppl 1:61-71. Slide 19,20
   
7. Wurtman J and Wurtman R. Curr Obes. Rep. 2018 Mar;7(1):1-5.
8. Ho KY, et al. Br J Anaesth. 2010 Setp;105(3):371-6.
9. Hull EM, et al. Physiology and Behavior. 2004 Nov;83(2):291-307.
10. Crowell MD. Br J Pharmacol. 2004 Apr;141(8):1285-93.
11. Rybaczy LA, et al. BMC Women’s Health. 2005. 
12. Yonkers KA, et al. ancet. 2008 Apr 5;371(9619):1200-1210.
13. Bravo R, et. al. Age (Dordr). 2013 Aug;35(4):1277-86.
14. Tauscher J, et al. The Amer J of Psychiatry. 2001 Aug 1;158(8):1326-1328.
15. Lynch JW. Physiol Rev. 2004 Oct ;84(4):1051-95. 
16. Miraucourt LS, et al. J Neurosci. 2009 Feb 25;29(8):2519-27. 
17. O’Byrne J,  et al. J Biol Chem. 2003 Sep 5;278(36):34237-44. 
18. McCarty MF, O’Keefe JH, DiNicolantonio JJ. Ochsner J. 2018 ;18(1):81-87. 
19. Meléndez-Hevia E, et al. J Biosci. 2009 Dec ;34(6):853-72.
20. Frenkel L, Muraro NI, Beltrán González AN, et al. (2017 Apr 4). Organization of Circadian Behavior Relies on Glycinergic Transmission. Cell Rep. 19(1):72-85.